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Airway and Circulating Levels of Carotenoids in Asthma and Healthy Controls

Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital (L.G.W., P.G.G.), Newcastle, New South Wales, AUSTRALIA
Nutrition and Dietetics, School of Health Sciences, Faculty of Health, University of Newcastle (M.L.G., R.J.B., S.G.-C.), Newcastle, New South Wales, AUSTRALIA

View larger version (15K): [in a new window]   Fig. 1. Whole blood concentrations in asthma versus controls of a.) Total Carotenoids (ap = 0.004), b.) Lycopene (bp = 0.003) and c.) ß-carotene (cp = 0.009).

View larger version (15K): [in a new window]   Fig. 2. Plasma versus Induced Sputum Concentrations of a.) Total Carotenoids (r = 0.798, p < 0.001), b.) Lycopene (r = 0.596, p = 0.041) and c.) ß-carotene (r = 0.845, p < 0.001) in asthma and control subjects. Data has been log transformed for analysis. Note that the number of data points varies because only non-zero concentrations are retained when data is log transformed.

View larger version (16K): [in a new window]   Fig. 3. Change in () Sputum Lycopene Concentrations versus Plasma Lycopene Concentrations following 4 weeks supplementation with 20 mg/day lycopene (r = 0.908, p = 0.002).

View larger version (20K): [in a new window]   Fig. 4. Induced Sputum Concentrations of Lycopene before and after 4 weeks supplementation with 20 mg/day lycopene (p > 0.05).