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Gamma-Cyclodextrin Lowers Postprandial Glycemia and Insulinemia without Carbohydrate Malabsorption in Healthy Adults

Michelle L. Asp, MS, RD, LD, Steven R. Hertzler, PhD, RD, JoMay Chow, PhD and Bryan W. Wolf, PhD

Medical Dietetics Division, School of Allied Medical Professions, College of Medicine and Public Health (M.L.A.)
Department of Human Nutrition, College of Human Ecology (S.R.H.)
The Ohio State University, Ross Products Division, Abbott Laboratories (J.C., B.W.W.) Columbus, Ohio


Figure 1
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  		Fig. 1. Postprandial plasma glucose response for subjects consuming 50 g of carbohydrate from maltodextrin ({circ}) or gamma-cyclodextrin (•) in a crossover design. Letters represent treatment differences for that time point (P < 0.001). Values are mean ± SEM, n = 31–32.

 

Figure 2
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  		Fig. 2. Postprandial serum insulin response for subjects consuming 50 g of carbohydrate from maltodextrin ({circ}) or gamma-cyclodextrin (•) in a crossover design. Letters represent treatment differences for that time point (P < 0.05). Values are mean ± SEM, n = 29–32.

 

Figure 3
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  		Fig. 3. Postprandial breath hydrogen response for subjects consuming 50 g of carbohydrate from maltodextrin ({circ}) or gamma-cyclodextrin (•) in a crossover design. Letters represent treatment differences for that time point (P < 0.05). Values are mean ± SEM, n = 29–32.

 

Figure 4
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  		Fig. 4. Intensity of subjective gastrointestinal tolerance symptoms during the first 24 h after subjects consumed 50 g of carbohydrate from maltodextrin (white bars) or gamma-cyclodextrin (black bars) in a crossover design. Intensity was set to a 10-cm line scale (0 representing [absent] and 10 [severe]). Values are mean ± SEM, n = 31–32.

 




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