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Effect of Concomitant Consumption of Fish Oil and Vitamin E on T Cell Mediated Function in the Elderly: A Randomized Double-Blind Trial

Dayong Wu, MD, PhD, Sung Nim Han, PhD, RD, Mohsen Meydani, DVM, PhD and Simin Nikbin Meydani, DVM, PhD

The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts


Figure 1
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  		Fig. 1. Correlation between plasma vitamin E and delayed-type hypersensitivity skin response. Healthy elderly subjects were supplemented with fish oil and different levels of vitamin E for 3 mo. Plasma samples were collected to determine the vitamin E concentrations using HPLC and DTH was assessed with a Multi-Test CMI, as described in the method section. Data are the post-supplementation measures from 34 subjects. There is a significant correlation (r = 0.565, p < 0.01) between the plasma {alpha}-tocopherol concentrations and DTH responses (total maximal induration).

 

Figure 2
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  		Fig. 2. Effect of dietary supplementation with fish oil and different levels of vitamin E on lymphocyte proliferation. Peripheral blood mononuclear cells (1 x 105) were stimulated with concanavalin A (Con A) or phytohemagglutinin (PHA) at 10 mg/L for 72 h and pulsed with [3H]thymidine during the last 4 h to determine DNA synthesis. Proliferation levels are expressed as average counts per minute (cpm). The unstimulated cells had a background count ranging from 70 to 100 cpm, which did not change after the supplementation. Data are mean ± SE, n = 8 to 10/group. * Significantly different from baseline at p < 0.05 (Student’s paired t test).

 




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