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Flaxseed Reduces Plasma Cholesterol Levels in Hypercholesterolemic Mouse Models

Institute for Translational Medicine and Therapeutics (M.A.P., J.T.B., L.T.B., P.O.S., D.J.R.)
Division of General Internal Medicine, General Clinical Research Center University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (P.O.S., L.T.B.)

View larger version (11K): [in this window] [in a new window]   Fig. 1. Plasma total cholesterol (panel A), non-HDL-C (panel B), HDL-C (panel C), and triglyceride (panel D) levels throughout the study for male hApoBtg mice fed either control (n = 7) or flax diets (n = 7).

View larger version (19K): [in this window] [in a new window]   Fig. 2. FPLC fraction cholesterol levels on day 21 in male (panel A) and female (panel B) from pooled plasma samples in hApoBtg mice fed either control or flax diets.

View larger version (10K): [in this window] [in a new window]   Fig. 3. Plasma total cholesterol (panel A), non-HDL-C (panel B), HDL-C (panel C), and triglyceride (panel D) levels throughout the study for female hApoBtg mice fed either control (n = 13) or flax (n = 12) diets.

View larger version (12K): [in this window] [in a new window]   Fig. 4. Plasma total cholesterol (panel A), non-HDL-C (panel B), HDL-C (panel C), and triglyceride (panel D) levels throughout the study for male LDLr–/–/apobec–/– mice fed either control (n = 6) or flax (n = 5) diets. *Different from control diet fed mice, p < 0.05.

View larger version (22K): [in this window] [in a new window]   Fig. 5. FPLC fraction cholesterol levels on day 21 from pooled plasma samples in male LDLr–/–/apobec–/– fed either control or flax diets.

View larger version (25K): [in this window] [in a new window]   Fig. 6. Hepatic lipid levels on day 21 in male (panel A) and female (panel B) hApoBtg mice and of male LDLr–/–/apobec–/– mice (Panel C) fed either control or flax diets. *Different from control diet fed mice, p < 0.05. Male hApoBtg: 7 mice/treatment; female hApoB: Flax, n = 13 and Control, n = 12; LDLr–/–/apobec–/–: Flax, n = 6 and Control, n = 5.