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Effect of Low Dose Antioxidant Vitamin and Trace Element Supplementation on the Urinary Concentrations of Thromboxane and Prostacyclin Metabolites

Josiane Arnaud, PhD, Muriel Bost, PhD, Dominique Vitoux, MD, José Labarère, MD PhD, Pilar Galan, MD, Henri Faure, PhD, Serge Hercberg, MD, PhD, Jean-Claude Bordet, PhD, Anne-Marie Roussel, PhD and Philippe Chappuis, PhD

SFERETE (Société Francophone d'Etudes et de Recherche sur les Eléments Toxiques et Essentiels) (J.A., M.B., D.V., H.F., S.H., A.-M.R, P.C.)
Département de Biologie Intégrée, CHU de Grenoble, Grenoble (J.A., H.F.), INSERM, U884, Grenoble, F-38000
Univ Grenoble, Grenoble, F-38000 (J.A., A.-M.R)
Trace Elément-Institut pour l'UNESCO, Le Condorcet, Lyon (M.B.), Laboratoire d'Analyse de Traces, Fédération de Biochimie, Hôpital Edouard Herriot, Lyon (M.B.)
Laboratoire de Biochimie A, Hôpital Saint-Louis, Paris (D.V.)
Unité d'Evaluation Médicale, CHU de Grenoble, Grenoble (J.L.), UMR U557 Inserm
U1125 Inra; Cnam; Paris 13 - CRNH d'lle de France - SMBH, Bobigny (P.G., S.H.)
Laboratoire d'Hémostase, Pavillon E, Hôpital Edouard Herriot, Lyon (J.-C.B.)
Laboratoire de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, Paris (P.C.), FRANCE


Figure 1
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  		Fig. 1. Effect of antioxidant supplement for 2 years on urinary 11-dehydro TXB2 2,3 dinor 6 keto PGF1{alpha}, and their ratio.

Fig. 1a: Effect of antioxidant supplement for 2 years on urinary 11-dehydro TXB2.

Fig. 1b: Effect of antioxidant supplement for 2 years on urinary 2,3 dinor 6 keto PGF1{alpha}.

Fig. 1c: Effect of antioxidant supplement for 2 years on urinary 11-dehydro TXB2/2,3 dinor 6 keto PG F1{alpha} ratio.

 

Figure 2
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  		Fig. 2. Proposed scheme for the effect of antioxidant on arachidonic acid and hence on thromboxane/prostacyclin ratio.

 




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