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Preliminary Evidence Shows That Folic Acid Fortification of the Food Supply Is Associated with Higher Methotrexate Dosing in Patients with Rheumatoid Arthritis

Senada Arabelovic, DO, Gina Sam, MD, Gerard E. Dallal, PhD, Paul F. Jacques, ScD, Jacob Selhub, PhD, Irwin H. Rosenberg, MD and Ronenn Roubenoff, MD, MHS

US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University (S.A., G.S., G.E.D., P.F.J., J.S. I.H.R., R.R.)
Division of Rheumatology/Immunology, Arthritis Treatment Center, Tufts-New England Medical Center (S.A., R.R.), Boston, Massachusetts


Figure 1
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  		Fig. 1. Average weekly dose of MTX per year. *p < 0.001, 1997-99 vs. 1988-96.

 




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