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Fig. 1. Observed effects of dietary fatty acids and related compounds on osteoblastic and osteoclastic activity in bone [44]. Excessive biosynthesis of PGE2 may depress bone formation and lead to increased bone resorption. Altering the production of eicosanoids (PGE and LTB) appears to optimize formation by osteoblasts perhaps by influencing IGF-I production and action [45].





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