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Fig. 2. Proposed mechanisms for the actions of CLA on PGE2 production (from AA) and bone metabolism. Block arrows indicate biochemical reaction processes where CLA and linoleic acid participate. Line arrows indicate possible effects of CLA and its metabolites on PGE2 metabolism and their subsequent action on bone [34]. Phospholipase A2=PLA2. Lipoxygenase enzyme=LO.





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