Fig. 3. Agouti modulation of adipocyte lipid metabolism. Agouti stimulates adipocyte Ca²⁺ influx. Increased adipocyte intracellular calcium ([Ca²⁺]i stimulates fatty acid synthase (FAS) transcription and activity, resulting in increased de novo lipogenesis, and also inhibits lipolysis. Consequently, adipocyte triglyceride stores are expanded.

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