Click on image to view larger version.
Fig. 4. Role of dietary calcium in modulating adipocyte lipid metabolism. 1,25-(OH)2-D stimulates adipocyte Ca2+ influx. This results in stimulation of fatty acid synthase (FAS) transcription and activity, increased de novo lipogenesis, and decreased lipolysis. Consequently, adipocyte triglyceride stores are expanded. Dietary calcium reduces the stimulus for Ca2+ influx by suppressing 1,25-(OH)2-D production, thereby permitting down-regulation of lipogenesis and up-regulation of lipolysis, resulting in reduced adipocyte triglyceride stores.
