Fig. 3. (a) ROS generated by microsomal monooxygenases, which have cytochrome P450 as a central link. Oxidation is the way to transform hydrophobic toxic substances, drugs, steroids etc., and thereby remove them. Excessive antioxidants can inhibit this protective function.

(b) ROS generated by phagocytes kill infectious microorganisms and cancer cells. Excessive antioxidants can inhibit this protective mechanism.

Return to article