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Fig. 4. Plots of the cumulative incidence of fractures, redrawn from the studies of Chapuy et al. [37] (bottom) and Dawson-Hughes et al. [38] (top). In both cases, the upper line represents the placebo control subjects, and the lower line represents the calcium and vitamin D-treated subjects. The shaded zones represent the reduction of fracture risk, which, as can be readily seen, starts with the very beginning of treatment. (Copyright Robert P. Heaney, 2004. Used with permission.)
