HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Robert, L. Articles by Rémésy, C. Search for Related Content PubMed PubMed Citation Articles by Robert, L. Articles by Rémésy, C.

Lipid Metabolism and Antioxidant Status in Sucrose vs. Potato-Fed Rats

INRA, Unité de Nutrition Humaine, Equipe Stress Métabolique et Micronutriments, Centre de Clermont-Ferrand/Theix Saint-Genès Champanelle, FRANCE

Address reprint requests to: A. Mazur, Unité de Nutrition Humaine, Equipe Stress Métabolique et Micronutriments, Institut National de Recherche Agronomique, Centre de Clermont-Ferrand/Theix, 63122 Saint-Genès Champanelle, FRANCE. E-mail: mazur{at}clermont.inra.fr

Objective: Consumption of high levels of simple carbohydrates is associated with several metabolic disorders in humans and in laboratory animals, including symptoms of an early stage of metabolic syndrome (syndrome X). This disorder has several cardiovascular risk factors, such as hypertriglyceridemia, and is associated with an increase in oxidative stress. In contrast to sucrose, potato, a source of complex carbohydrates and antioxidant micronutrients, was thought to improve lipid metabolism and antioxidant protection.

Methods: We investigated the effects of diets containing i) complex dietary carbohydrates and antioxidant micronutrients (potato Solanum tuberosum L.), ii) complex carbohydrates (starch) and iii) a simple carbohydrate (sucrose) on lipid metabolism and antioxidant status in rats.

Results: An increase in short chain fatty acid (SCFA) pools was observed in the cecum of rats fed a potato-based diet, resulting from an increase in all SCFAs, especially propionate (+360%, P < 0.0001). Feeding rats a potato-based diet for 3 weeks led to a decrease in cholesterol (–37%, potato vs. control and –32%, potato vs. sucrose) and triglycerides (–31%, potato vs. control and –43%, potato vs. sucrose) concentrations in triglyceride-rich lipoproteins (TGRLP) fractions. The antioxidant status was decreased by sucrose consumption and improved by potato consumption.

Conclusions: Our present results suggest that consumption of complex carbohydrates (provided as cooked potatoes), in combination with different antioxidant micronutrients, may enhance the antioxidant defences and improve lipid metabolism, when compared with starch (complex carbohydrates) and to sucrose consumption (source of simple sugar). These effects limit oxidative stress and reduce the risk of developing the associated degenerative diseases, including cardiovascular disease, and could have potential in cardiovascular disease prevention.

Key words: potato, sucrose, carbohydrates, cardiovascular disease, antioxidant status

This article has been cited by other articles:

				M. K. Pickens, J. S. Yan, R. K. Ng, H. Ogata, J. P. Grenert, C. Beysen, S. M. Turner, and J. J. Maher Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis J. Lipid Res., October 1, 2009; 50(10): 2072 - 2082. [Abstract] [Full Text] [PDF]