JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roussel, A.-M.
Right arrow Articles by Anderson, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roussel, A.-M.
Right arrow Articles by Anderson, R. A.
Journal of the American College of Nutrition, Vol. 28, No. 1, 16-21 (2009)
Published by the American College of Nutrition

Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese

Anne-Marie Roussel, PhD, FACN, Isabelle Hininger, PhD, Rachida Benaraba, MS, Tim N. Ziegenfuss, PhD and Richard A. Anderson, PhD, FACN

INSERM, U884 (A.-M.R., I.H., R.B.), LBFA, Université
Joseph Fourier (A.-M.R., I.H., R.B.), Grenoble, FRANCE
Ohio Research Group, Wadsworth, Ohio (T.N.Z.)
Beltsville Human Nutrition Research Center, USDA, Beltsville, Maryland (R.A.A.)

Address correspondence to: Dr. Richard A. Anderson; USDA, ARS, BHNRC, DGIL; Bldg. 307C, Rm. 222, BARC-East; Beltsville, MD 20705-2350. E-mail: Richard.Anderson{at}ars.usda.gov

Objective: To determine the effects of a dried aqueous extract of cinnamon on antioxidant status of people with impaired fasting glucose that are overweight or obese.

Methods: Twenty-two subjects, with impaired fasting blood glucose with BMI ranging from 25 to 45, were enrolled in a double-blind placebo-controlled trial. Subjects were given capsules containing either a placebo or 250 mg of an aqueous extract of cinnamon (Cinnulin PF) two times per day for 12 weeks. Plasma malondialdehyde (MDA) concentrations were assessed using high performance liquid chromatography and plasma antioxidant status was evaluated using ferric reducing antioxidant power (FRAP) assay. Erythrocyte Cu-Zn superoxide (Cu-Zn SOD) activity was measured after hemoglobin precipitation by monitoring the auto-oxidation of pyrogallol and erythrocyte glutathione peroxidase (GPx) activity by established methods.

Results: FRAP and plasma thiol (SH) groups increased, while plasma MDA levels decreased in subjects receiving the cinnamon extract. Effects were larger after 12 than 6 weeks. There was also a positive correlation (r = 0.74; p = 0.014) between MDA and plasma glucose.

Conclusion: This study supports the hypothesis that the inclusion of water soluble cinnamon compounds in the diet could reduce risk factors associated with diabetes and cardiovascular disease.

Key words: cinnamon, antioxidants, glucose, diabetes, insulin






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the American College of Nutrition.