Fig. 2. Upper Panel: Changes in brachial artery flow-mediated dilation (FMD) compared to pretreatment are displayed for Placebo and EGCG. FMD improved two hours after a single 300 mg dose of EGCG (*P = 0.01), while FMD was not changed after two weeks of EGCG 150 mg twice daily (P = 0.12). Placebo had no effect at the two-hour and two-week time points. Lower Panel: Changes in plasma EGCG concentration compared to pre-treatment concentration are displayed for Placebo and EGCG (n = 38). Plasma ECGC concentrations were increased two hours after a single 300 mg dose of EGCG (P < 0.001), while trough plasma EGCG concentrations (approximately 14 hours after the last dose) were unchanged after two weeks of EGCG 150 mg twice daily. Data are mean ± SEM.