Journal of the American College of Nutrition, Vol 12, Issue 5 501-504, Copyright © 1993 by American College of Nutrition

CLINICAL TRIAL

Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report

M. L. Bierenbaum, R. Reichstein and T. R. Watkins
Kenneth L. Jordan Heart Fund, Montclair, New Jersey 07040.

The effect on serum lipids of a flax seed supplement consisting of three slices of flax seed-containing bread and 15 g of ground flax seed was studied in 15 hyperlipemic subjects on long-term intake (800 IU/day) of vitamin E. The flax seed, which was high in alpha-linolenic acid and fiber, and which has been reported to lower serum cholesterol in elderly subjects, was provided in a 3-month feeding trial. Serum total and low-density lipoprotein cholesterol levels were reduced significantly; high-density lipoprotein cholesterol did not change during flax seed consumption. Thrombin-stimulated platelet aggregation decreased with the supplement. Serum lipid oxidation products decreased significantly during the washout period.

This article has been cited by other articles:

				N. Kaul, R. Kreml, J. A. Austria, M. N. Richard, A. L. Edel, E. Dibrov, S. Hirono, M. E. Zettler, and G. N. Pierce A Comparison of Fish Oil, Flaxseed Oil and Hempseed Oil Supplementation on Selected Parameters of Cardiovascular Health in Healthy Volunteers J. Am. Coll. Nutr., February 1, 2008; 27(1): 51 - 58. [Abstract] [Full Text] [PDF]

				L. T. Bloedon, S. Balikai, J. Chittams, S. C. Cunnane, J. A. Berlin, D. J. Rader, and P. O. Szapary Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial J. Am. Coll. Nutr., February 1, 2008; 27(1): 65 - 74. [Abstract] [Full Text] [PDF]

				C. M. C. Dupasquier, A.-M. Weber, B. P. Ander, P. P. Rampersad, S. Steigerwald, J. T. Wigle, R. W. Mitchell, E. A. Kroeger, J. S. C. Gilchrist, M. M. Moghadasian, et al. Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2987 - H2996. [Abstract] [Full Text] [PDF]

				C. R. Harper, M. C. Edwards, and T. A. Jacobson Flaxseed Oil Supplementation Does Not Affect Plasma Lipoprotein Concentration or Particle Size in Human Subjects J. Nutr., November 1, 2006; 136(11): 2844 - 2848. [Abstract] [Full Text] [PDF]

				C. Stuglin and K. Prasad Effect of Flaxseed Consumption on Blood Pressure, Serum Lipids, Hemopoietic System and Liver and Kidney Enzymes in Healthy Humans Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2005; 10(1): 23 - 27. [Abstract] [PDF]

				J. D. Spence, T. Thornton, A. D. Muir, and N. D. Westcott The Effect of Flax Seed Cultivars with Differing Content of {alpha}-Linolenic Acid and Lignans on Responses to Mental Stress J. Am. Coll. Nutr., December 1, 2003; 22(6): 494 - 501. [Abstract] [Full Text] [PDF]

				S. J. Bhathena, A. A. Ali, C. Haudenschild, P. Latham, T. Ranich, A. I. Mohamed, C. T. Hansen, and M. T. Velasquez Dietary Flaxseed Meal is More Protective Than Soy Protein Concentrate Against Hypertriglyceridemia and Steatosis of the Liver in an Animal Model of Obesity J. Am. Coll. Nutr., April 1, 2003; 22(2): 157 - 164. [Abstract] [Full Text] [PDF]

				A. Lemay, S. Dodin, N. Kadri, H. Jacques, and J.-C. Forest Flaxseed Dietary Supplement Versus Hormone Replacement Therapy in Hypercholesterolemic Menopausal Women Obstet. Gynecol., September 1, 2002; 100(3): 495 - 504. [Abstract] [Full Text] [PDF]

				W. J Craig Health-promoting properties of common herbs Am. J. Clinical Nutrition, September 1, 1999; 70(3): 491S - 499. [Abstract] [Full Text] [PDF]

				D. J. Jenkins, C. W. Kendall, E. Vidgen, S. Agarwal, A V. Rao, R. S Rosenberg, E. P Diamandis, R. Novokmet, C. C Mehling, T. Perera, et al. Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial Am. J. Clinical Nutrition, March 1, 1999; 69(3): 395 - 402. [Abstract] [Full Text] [PDF]

				P. J. Nestel, S. E. Pomeroy, T. Sasahara, T. Yamashita, Y. L. Liang, A. M. Dart, G. L. Jennings, M. Abbey, and J. D. Cameron Arterial Compliance in Obese Subjects Is Improved With Dietary Plant n-3 Fatty Acid From Flaxseed Oil Despite Increased LDL Oxidizability Arterioscler. Thromb. Vasc. Biol., June 1, 1997; 17(6): 1163 - 1170. [Abstract] [Full Text]