HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Prasad, K. N. Articles by Prasad, K. C. Search for Related Content PubMed PubMed Citation Articles by Prasad, K. N. Articles by Prasad, K. C.

Scientific Rationale for Using High-Dose Multiple Micronutrients as an Adjunct to Standard and Experimental Cancer Therapies

Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center (K.N.P., W.C.C., B.K.), Denver, Colorado
Department of Pathology, University of California (K.C.P.), San Francisco, California

Address reprint requests to: Kedar N. Prasad, PhD, UCHSC, Dept. of Radiology, Box C278, 4200 E. 9th Avenue, Denver, CO 80262. E-mail: Kedar.prasad{at}UCHSC.edu

We have hypothesized that high-dose multiple micronutrients, including antioxidants, as an adjunct to standard (radiation therapy and chemotherapy) or experimental therapy (hyperthermia and immunotherapy), may improve the efficacy of cancer therapy by increasing tumor response and decreasing toxicity. Several in vitro studies and some in vivo investigations support this hypothesis. A second hypothesis is that antioxidants may interfere with the efficacy of radiation therapy and chemotherapy. This hypothesis is based on the concept that antioxidants will destroy free radicals that are generated during therapy, thereby protecting cancer cells against death. None of the published data on the effect of antioxidants in combination with radiation or chemotherapeutic agents on tumor cells supports the second hypothesis. Scientific rationale in support of a micronutrient protocol to be used as an adjunct to standard or experimental cancer therapy is presented.

Key words: antioxidants, cancer therapy, hyperthermia, sodium butyrate, cAMP

This article has been cited by other articles:

				B. D. Lawenda, K. M. Kelly, E. J. Ladas, S. M. Sagar, A. Vickers, and J. B. Blumberg Should Supplemental Antioxidant Administration Be Avoided During Chemotherapy and Radiation Therapy? J Natl Cancer Inst, June 4, 2008; 100(11): 773 - 783. [Abstract] [Full Text] [PDF]

				K. N. Prasad Rationale for Using High-Dose Multiple Dietary Antioxidants as an Adjunct to Radiation Therapy and Chemotherapy J. Nutr., November 1, 2004; 134(11): 3182S - 3183S. [Full Text] [PDF]

				E. J. Ladas, J. S. Jacobson, D. D. Kennedy, K. Teel, A. Fleischauer, and K. M. Kelly Antioxidants and Cancer Therapy: A Systematic Review J. Clin. Oncol., February 1, 2004; 22(3): 517 - 528. [Abstract] [Full Text] [PDF]

				H. E. Seifried, S. S. McDonald, D. E. Anderson, P. Greenwald, and J. A. Milner The Antioxidant Conundrum in Cancer Cancer Res., August 1, 2003; 63(15): 4295 - 4298. [Abstract] [Full Text] [PDF]

				D. Tripathy Clinical Testing of Supplementation Therapy in Early Stage Breast Cancer: Pitfalls and Opportunities Integr Cancer Ther, June 1, 2003; 2(2): 160 - 162. [PDF]

				J. A. Drisko, J. Chapman, and V. J. Hunter The Use of Antioxidants with First-Line Chemotherapy in Two Cases of Ovarian Cancer J. Am. Coll. Nutr., April 1, 2003; 22(2): 118 - 123. [Abstract] [Full Text] [PDF]

				B. Kumar, M. N. Jha, W. C. Cole, J. S. Bedford, and K. N. Prasad D-Alpha-Tocopheryl Succinate (Vitamin E) Enhances Radiation-Induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells J. Am. Coll. Nutr., August 1, 2002; 21(4): 339 - 343. [Abstract] [Full Text] [PDF]