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Journal of the American College of Nutrition, Vol. 23, No. 5, 549S-551S (2004)
Published by the American College of Nutrition

The Influence of Some Antipsychotics on Erythrocyte Magnesium and Plasma Magnesium, Calcium, Copper and Zinc in Patients with Paranoid Schizophrenia

Mihai Nechifor, C. Vaideanu, I. Palamaru, C. Borza and I. Mindreci

Department of Pharmacology (M.N., C.V.), University of Medicine and Pharmacy "Gr. T. Popa" Iasi, ROMANIA
Institute of Hygiene Public Health (P.I.), University of Medicine and Pharmacy "Gr. T. Popa" Iasi, ROMANIA
Department of Psychiatry (C.B.), University of Medicine and Pharmacy "Gr. T. Popa" Iasi, ROMANIA
Department of Biophysics (I.M.), University of Medicine and Pharmacy "Gr. T. Popa" Iasi, ROMANIA

Address reprint requests to: Nechifor Mihai, Department of Pharmacology, University of Medicine and Pharmacy, "Gr. T. Popa" Iasi, Str. Universita'tii nr. 16, Iasi, 700115, ROMANIA. E-mail: mnechif{at}iasi.mednet.ro

Objective: The aim of the study was the investigation of plasma magnesium, calcium, copper and zinc and erythrocyte magnesium levels in patients with paranoid schizophrenia and the influence of the therapy with two antipsychotic drugs (haloperidol and risperidone) on these concentrations.

Methods: We investigated the influence of treatment with haloperidol and risperidoneon plasma and erythrocyte magnesium and on plasmatic levels of zinc, calcium and copper on hospitalized 56 patients diagnosed with paranoid schizophrenia (DSM IV).

Results: Our data indicate a decrease of erythrocyte magnesium levels in schizophrenic patients (4.82 ± 3.1 mg/L vs. 59.2 ± 1.1 mg/L in control group, p < 0.01). The plasma level of magnesium was unchanged (18.9 ± 2.17 mg/L in schizophrenic patients vs. 18.26 ± 1.9 mg/L in control group).

Conclusions: We consider plasma Cu2+/erythrocyte Mg2+ and plasma Cu2+/Zn2+ ratio two important biological markers of the acute paranoid schizophrenia.

Key words: erythrocyte Mg, plasma Mg, plasma Ca, Cu, Zn, paranoid schizophrenia, antipsychotic drugs, haloperidol, risperidone






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