JACN
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Silver, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Silver, B. B.
Journal of the American College of Nutrition, Vol. 23, No. 6, 732S-737S (2004)
Published by the American College of Nutrition

Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

Burton B. Silver, PhD

University of Louisville, School of Medicine, Department of Physiology & Biophysics, Louisville, Kentucky (Ret), and IntraCellular Diagnostics, Inc., Foster City, California

Address reprint requests to: Burton B. Silver, Ph.D., IntraCellular Diagnostics, Inc. 553 Pilgrim Dr (B), Foster City, CA. E-mail: DocBurt{at}aol.com

A novel technique, using energy dispersive X-ray microanalysis (EXA tm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg 2+] i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg 2+ is found in the intravascular space, serum levels of Mg 2+ give little information about a patient’s overall Mg 2+ status with respect to this essential mineral. Using the EXA tm analysis it has shown been determined that Mg 2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg 2+] i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg 2+ deficiency. Examples of the application of EXA tm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA [12].

Key words: x-ray microanalysis, nano-analysis, cellular magnesium, non-invasive measurement






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American College of Nutrition.