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Journal of the American College of Nutrition, Vol. 27, No. 1, 22-30 (2008)
Published by the American College of Nutrition

Safety Aspects and Cholesterol-Lowering Efficacy of Chitosan Tablets

Niina S. Tapola, MSc, RD, Mari L. Lyyra, MSc, RD, Riikka M. Kolehmainen, MD, Essi S. Sarkkinen, PhD, RD and Alexander G. Schauss, PhD, FACN

Oy Foodfiles Ltd, Neulaniementie (N.S.T., M.L.R. R.M.K., E.S.S.)
Department of Gynecology, Kuopio University Hospital (R.M.K.)
Kuopio, FINLAND, Natural and Medicinal Products Research Division, AIBMR Life Sciences, Inc., Puyallup, Washington (A.G.S.)

Address reprint requests to: Alexander G. Schauss, PhD, FACN, Natural and Medicinal Products Research Division, AIBMR Life Sciences, Inc., 4117 S. Meridian, Puyallup, WA 98373. E-mail: alex{at}aibmr.com

Objective: The purpose of this study was to determine the effect of two different doses of chitosan on serum fat-soluble vitamin concentrations, cholesterol concentrations, and other safety parameters.

Methods: A total of 65 men and women consumed 0, 4.5, 6.75 g per day of chitosan or 6.75 g per day glucomannan for eight weeks in a parallel, placebo-controlled, single-blind study. Altogether, 56 participants completed the study.

Results: No differences were detected among the treatments in serum vitamins (vitamin A, vitamin E, 25-hydroxyvitamin D), carotenes ({alpha}- and β-carotene), clinical chemistry or hematology measurements. The changes in the total and LDL-cholesterol concentrations among the study groups were not statistically significant.

Conclusion: In the present study, the consumption of chitosan tablets was found to be safe, but there was no significant effect on cholesterol concentration.

Key words: chitosan, carotenoids, fat-soluble vitamins, safety, cholesterol, lipoproteins, glucomannan

Abbreviations: 25(OH)D = 25-hydroxyvitamin D • LDL = low density lipoprotein • HDL = high density lipoprotein • GLM = general linear model






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