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Journal of the American College of Nutrition, Vol. 27, No. 2, 356-366 (2008)
Published by the American College of Nutrition

A Novel Resistant Maltodextrin Alters Gastrointestinal Tolerance Factors, Fecal Characteristics, and Fecal Microbiota in Healthy Adult Humans

Nathaniel D. Fastinger, PhD, Lisa K. Karr-Lilienthal, PhD, Julie K. Spears, PhD, Kelly S. Swanson, PhD, Krista E. Zinn, MS, Gerardo M. Nava, MS, Kazuhiro Ohkuma, PhD, Sumiko Kanahori, MS, Dennis T. Gordon, PhD and George C. Fahey, Jr, PhD

Department of Animal Sciences, University of Illinois at Urbana-Champaign (N.D.F., L.K.K.-L., J.K.S., K.S.S., K.E.Z., G.M.N., G.C.F.)
Urbana, Illinois, Matsutani Chemical Industry Co., Ltd, Hyoga, JAPAN (K.O., S.K., D.T.G.)

Address reprint requests to: G. C. Fahey, Jr., Ph.D., Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 132 Animal Sciences Laboratory, 1207 West Gregory Drive, Urbana, IL 61801. E-mail: gcfahey{at}uiuc.edu

Objective: Resistant maltodextrin has been shown to increase fecal bulk by resisting digestion and being partially fermented by colonic bacteria to short-chain fatty acids (SCFA). The objective of this experiment was to determine potential prebiotic effects, gastrointestinal tolerance, and fecal characteristics of free-living humans fed a novel resistant maltodextrin or a normal maltodextrin control.

Methods: Subjects (n = 38) were enrolled in a randomized, double-blind study where they were assigned to one of three daily treatments: 15 g maltodextrin; 7.5 g maltodextrin plus 7.5 g resistant maltodextrin (Fibersol-2®; Matsutani Chemical Company, Hyogo, Japan); and 15 g resistant maltodextrin. The experiment lasted 7 wk and consisted of a 2 wk baseline period, a 3 wk treatment period, and a 2 wk washout period. During wk 3 to 5 (treatment period), subjects consumed their assigned treatments.

Results: Resistant maltodextrin supplementation tended to increase (p = 0.12) fecal Bifidobacterium populations during the treatment period, altered (p < 0.05) bacterial populations from baseline to treatment, and resulted in very minor effects in gastrointestinal tolerance. There was a shift (p < 0.05) in molar proportions of SCFA towards butyrate, the preferred energy substrate of colonocytes.

Conclusion: Resistant maltodextrin supplementation was well tolerated, resulted in favorable fermentation characteristics in the large bowel, and also resulted in a change in bacterial populations.

Key words: human subjects, available carbohydrate, fermentable carbohydrate, prebiotic, dietary fiber, fecal microbiota

Abbreviations: CFU = colony forming unit • DGGE = denaturing gradient gel electrophoresis • PCR = polymerase chain reaction • qPCR = quantitative real-time polymerase chain reaction • SCFA = short-chain fatty acids






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