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Journal of the American College of Nutrition, Vol. 27, No. 4, 463-469 (2008)
Published by the American College of Nutrition

No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study

Maud Andriollo-Sanchez, PhD, Isabelle Hininger-Favier, PhD, Nathalie Meunier, PhD, Eugenia Venneria, MSc, Jacqueline M. O'Connor, DPhil, Giuseppe Maiani, PhD, Angela Polito, PhD, Séverine Bord, Monique Ferry, MD, PhD, Charles Coudray, PhD and Anne-Marie Roussel, PhD, FACN

INSERM and LBFA, Université J. Fourier, Grenoble (M.A.S., I.H.F., A.M.R.)
Centre de Recherche en Nutrition Humaine d'Auvergne (C.R.N.H.)
Unité Maladies Métaboliques et Micronutriments, INRA, St Genès-Champanelle (N.M., C.C.)
Epidémiologie Animale, INRA, Centre de Recherche de Clermont-Ferrand/Theix (S.B.)
Centre Hospitalier de Valence, Valence (M.F.)
FRANCE, National Institute for Food and Nutrition Research (INRAN), Human Nutrition Unit, Rome, ITALY (E.V., G.M., A.P.)
NICHE, Biomedical Science, University of Ulster, Coleraine, Northern Ireland, UNITED KINGDOM (J.M.O.C.)

Address reprint requests to: Pr Anne-Marie Roussel, Laboratoire de Nutrition, Vieillissement et Maladies Cardiovasculaires (NVMC), Faculté de Pharmacie, Domaine de la Merci, 38706 La Tronche Cedex, FRANCE. E-mail: Anne-Marie.Roussel{at}ujf-grenoble.fr

Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people.

Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control.

Setting: France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine).

Subjects: A total of 387 healthy middle-aged (55–70 yrs) and free-living older aged (70–85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months.

Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months.

Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity.

Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.






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Copyright © 2008 by the American College of Nutrition.