Journal of the American College of Nutrition, Vol 9, Issue 5 500-502, Copyright © 1990 by American College of Nutrition

JOURNAL ARTICLE

Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?

H. G. Classen, C. Stein-Hammer and H. Thoni
Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Stuttgart, FRG.

Increasing doses of nitrite (3.7-14.8 mg/kg BW) were administered via intragastric intubation to 64 spontaneously hypertensive Sprague-Dawley rats. Systemic blood pressure, measured in conscious animals with the tail cuff method, significantly decreased in a dose-related manner 16 and 32 minutes later, and pulse rate slightly increased. Since orally ingested nitrate may be partially converted to nitrite, it seems worthwhile to study correlations between dietary nitrate and blood pressure in experimental animals and man.

This article has been cited by other articles:

				Y. Kanematsu, K. Yamaguchi, H. Ohnishi, Y. Motobayashi, K. Ishizawa, Y. Izawa, K. Kawazoe, S. Kondo, S. Kagami, S. Tomita, et al. Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1457 - F1462. [Abstract] [Full Text] [PDF]

				J. O. Lundberg and E. Weitzberg NO Generation From Nitrite and Its Role in Vascular Control Arterioscler Thromb Vasc Biol, May 1, 2005; 25(5): 915 - 922. [Abstract] [Full Text] [PDF]

				K. Tsuchiya, Y. Kanematsu, M. Yoshizumi, H. Ohnishi, K. Kirima, Y. Izawa, M. Shikishima, T. Ishida, S. Kondo, S. Kagami, et al. Nitrite is an alternative source of NO in vivo Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2163 - H2170. [Abstract] [Full Text] [PDF]