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Metabolism of Selenite in Men with Widely Varying Selenium Status

BioChemAnalysis Corp and the Center for Stable Isotope research Inc, 2201 West Campbell Park Drive, Chicago, Illinois (M.J.)
Chinese Academy of Preventive Medicine, Institute of Nutrition and Food Hygiene, Beijing, People’s Republic of CHINA (Y.X., P.H.)
Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon (P.D.W., J.A.B.)
Microscopic and Chemical Analysis Research Center, Ohio State University, Columbus, Ohio (J.W.O., L.D.)

View larger version (21K): [in a new window]   Fig. 1. Simplified scheme for metabolism of dietary intake of selenium.

View larger version (19K): [in a new window]   Fig. 2. Comparison of low Se subjects with high Se ones for the measurement of urine Se originating from endogenous Se turnover. The data are presented as 24-hour excretion for day 0, mean of 7 days for days 1 to 7 and mean of 6 days for days 2 to 7.

View larger version (17K): [in a new window]   Fig. 3. Observed quantitative relationship between estimated long-term Se intake and daily urinary excretion of endogenous origin using all subjects (A) as compared to low and adequate subjects (B).

View larger version (19K): [in a new window]   Fig. 4. Urine excretion kinetics of infused selenite in the three experimental groups of low selenium, adequate selenium and high selenium (first and second infusions).

View larger version (21K): [in a new window]   Fig. 5. Observed relationship between 5-day (2 to 7) cumulative urinary excretion of infused selenite and daily excretion of endogenous Se.

View larger version (19K): [in a new window]   Fig. 6. Plot of individual data for each subject showing the relationship between daily excretion in urine of endogenous, or labeled Se, and estimated long-term Se intake.

View larger version (14K): [in a new window]   Fig. 7. Kinetics of turnover of plasma label for each group (A) and a plot of the semilogrithim of pooled data (B).