Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during "The Marathon des Sables"

Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during "The Marathon des Sables"

Guillaume Machefer, PhD, Carole Groussard, PhD, Sophie Vincent, PhD, Hassane Zouhal, PhD, Henri Faure, PhD, Josiane Cillard, PhD, Zsolt Radák, PhD and Arlette Gratas-Delamarche, PhD

Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.)
G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)
Laboratory of Cellular and Plant Biology, Faculty of Pharmacy, University of Rennes 1 (J.C.), Rennes Cedex
Department of Integrated Biology, CHUG, Grenoble (H.F.), FRANCE
Department of Exercise Physiology, School of Sport Science, Semmelweiss University Budapest, Budapest, HUNGARY (Z.R.)

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Fig. 1. Plasma Thiobarbituric Reactive Substances (TBARS) (A) and Reactive Carbonyl Derivatives (RCD) (B) levels in Supplemented ( ${square}$ ) and Placebo ( ${blacksquare}$ ) group at the beginning of the study (D-21), after 19 days of supplementation (D-2), during (D3) and at the end (D7) of the competition. Results are expressed as means as ± SEM where 100% value represents value at D-21. In each group, the values not sharing the same letter were significantly different at p < 0.05. $ indicated significant differences between P and S group at p < 0.05.

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Fig. 2. Plasma creatine kinase (CK) (A) and lactate dehydrogenase (LDH) (B) activities in Supplemented ( ${square}$ ) and Placebo ( ${blacksquare}$ ) group at the beginning of the study (D-21), after 19 days of supplementation (D-2), during (D3) and at the end (D7) of the competition. Results are expressed as means as ± SEM where 100 % value represents value at D-21. In each group, the values not sharing the same letter were significantly different at p < 0.05.

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Fig. 3. Erythrocyte glutathione peroxidase (GPx) (A), superoxide dismutase (SOD) (B) activities and reduced glutathione (GSH) level (C) in Supplemented ( ${square}$ ) and Placebo ( ${blacksquare}$ ) group at the beginning of the study (D-21), after 19 days of supplementation (D-2), during (D3) and at the end (D7) of the competition. Results are expressed as means as ± SEM where 100 % value represents value at D-21. In each group, the values not sharing the same letter were significantly different at p < 0.05.

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Fig. 4. Plasma acid uric (A) and retinol (B) levels in Supplemented ( ${square}$ ) and Placebo ( ${blacksquare}$ ) group at the beginning of the study (D-21), after 19 days of supplementation (D-2), during (D3) and at the end (D7) of the competition. Results are expressed as means as ± SEM where 100 % value represents value at D-21. In each group, the values not sharing the same letter were significantly different at p < 0.05.

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Fig. 5. Plasma vitamin C (A) ${alpha}$ -tocopherol (B) and ß-carotene (C) levels in Supplemented ( ${square}$ ) and Placebo ( ${blacksquare}$ ) group at the beginning of the study (D-21), after 19 days of supplementation (D-2), during (D3) and at the end (D7) of the competition. Results are expressed as means as ± SEM where 100 % value represents value at D-21. In each group, the values not sharing the same letter were significantly different at p < 0.05. $ indicated significant differences between P and S group at p < 0.05.