Fig. 1. Melanoma cells (10⁵) were plated in tissue culture dishes (60 mm), and d--tocopheryl succinate (-TS) and sodium succinate plus ethanol were added to separate cultures 24 hours after plating. Drugs and medium were changed at two and three days after treatment. Photomicrographs were taken four days after treatment. Control cultures showed fibroblastic cells as well as round cells in clumps (a); cultures treated with ethanol (1%) and sodium succinate (5–6 µg/mL) also exhibited fibroblastic morphology with fewer round cells (b); -TS-treated cultures 5 µg/mL (c), and 6 µg/mL (d) showed a dramatic change in morphology [41].

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