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Fig. 9. Photomicrographs of murine melanoma were taken four days after treatment. Control culture contained cells with varied morphology (a). The melanoma cells treated with vitamin E succinate (b) were elongated, had long cytoplasmic processes, and were arranged alongside each other. Melanoma cells treated with RO20-1724 (c) were large and elongated, had some long processes, and were arranged alongside each other. A combination of RO20-1724 and vitamin E succinate (d) increased the level of morphologic differentiation more than that produced by individual agents [56].
